abstract：PURPOSE:Breast-conserving therapy (BCT) is an accepted method of treating early breast cancer. We hypothesized that routine excision of additional cavity shave margins (CSM) at time of initial partial mastectomy reduces the need for additional surgery. METHODS:A single-institution retrospective review was performed of...

journal_title：Annals of surgical oncology

authors： Kobbermann A,Unzeitig A,Xie XJ,Yan J,Euhus D,Peng Y,Sarode V,Moldrem A,Marilyn Leitch A,Andrews V,Stallings C,Rao R

更新日期：2011-05-01 00:00:00

abstract：BACKGROUND:Hepatic resection for colorectal liver metastasis (CLM) with concomitant extrahepatic disease (EHD) is a controversial topic. We sought to evaluate the long-term outcome of patients undergoing liver resection for CLM in presence of EHD and identify factors associated with prognosis. METHODS:From 1996 to 200...

journal_title：Annals of surgical oncology

authors： Pulitanò C,Bodingbauer M,Aldrighetti L,de Jong MC,Castillo F,Schulick RD,Parks RW,Choti MA,Wigmore SJ,Gruenberger T,Pawlik TM

更新日期：2011-05-01 00:00:00

abstract：BACKGROUND:This study aimed to evaluate the prognostic impact of pT2 subclassification according to the depth of muscularis propria (MP) invasion and to explore the clinicopathologic factors correlated with lymph node metastasis (LNM) and postoperative hematogenous metastasis in pT2 colorectal cancer. METHODS:A total ...

journal_title：Annals of surgical oncology

authors： Tong LL,Gao P,Wang ZN,Yue ZY,Song YX,Sun Z,Lu Y,Xing CZ,Xu HM

更新日期：2011-05-01 00:00:00

abstract：BACKGROUND:Incidence rates of hypoparathyroidism and vocal cord paralysis are high following central compartment reoperation, but few prospective studies have assessed morbidities and factors predictive of hypocalcemia after reoperation. We investigated recurrence patterns, morbidity, and factors predictive of postoper...

journal_title：Annals of surgical oncology

authors： Roh JL,Kim JM,Park CI

更新日期：2011-05-01 00:00:00

abstract：BACKGROUND:Inguinofemoral lymphadenectomy is associated with frequent and marked incision-related morbidity. Our initial feasibility study of videoscopic inguinal lymphadenectomy (VIL) for melanoma showed appropriate nodal yield and anatomic dissection. Although a limited suprafascial dissection has been reported in th...

journal_title：Annals of surgical oncology

authors： Delman KA,Kooby DA,Rizzo M,Ogan K,Master V

更新日期：2011-04-01 00:00:00

abstract：BACKGROUND:With the recent development of molecular markers, it has become possible to characterize colorectal carcinomas beyond clinical and histologic aspects. When considered together with tumor stage, molecular markers will allow us further insight into individual tumor biologies and prognoses. PURPOSE:To investig...

journal_title：Annals of surgical oncology

authors： Kang H,Min BS,Lee KY,Kim NK,Kim SN,Choi J,Kim H

更新日期：2011-03-01 00:00:00

abstract：BACKGROUND:Patients with borderline resectable pancreatic ductal adenocarcinoma (PDA) represent a high-risk group of patients due to tumor or patient-related characteristics. The optimal management of these patients has not been fully defined. MATERIALS AND METHODS:All patients undergoing evaluation for PDA between 20...

journal_title：Annals of surgical oncology

authors： Stokes JB,Nolan NJ,Stelow EB,Walters DM,Weiss GR,de Lange EE,Rich TA,Adams RB,Bauer TW

更新日期：2011-03-01 00:00:00

abstract：BACKGROUND:Heat-shock protein gp96 plays an important role in antitumor immunoreactions. Gp96 has a close relationship with antitumor immunity. This study evaluated the correlation between gp96 expression and the prognosis in esophageal squamous cell carcinoma. METHODS:Seventy-eight patients with primarily resected es...

journal_title：Annals of surgical oncology

authors： Akutsu Y,Matsubara H,Kano M,Usui A,Yoneyama Y,Ikeda N,Komatsu A,Yusup G

更新日期：2011-03-01 00:00:00

abstract：BACKGROUND:The relationship between provider volume and complication and transfusion rates in patients undergoing minimally invasive prostatectomy (MIRP) for prostate cancer has not been assessed. Temporal trends in MIRP annual surgical caseload (AC), impact of MIRP surgical experience (SE), and in-hospital complicatio...

journal_title：Annals of surgical oncology

authors： Budäus L,Sun M,Abdollah F,Zorn KC,Morgan M,Johal R,Liberman D,Thuret R,Isbarn H,Salomon G,Haese A,Montorsi F,Shariat SF,Perrotte P,Graefen M,Karakiewicz PI

更新日期：2011-03-01 00:00:00

abstract：INTRODUCTION:The efficacy of laparoscopic celiac plexus block (CPB) in patients with unresectable pancreatic cancer has not been reported. METHODS:Patients with elevated pain scores scheduled for laparoscopy for diagnosis/staging of unresectable pancreatic adenocarcinoma were eligible. The study was designed to evalua...

journal_title：Annals of surgical oncology

authors： Allen PJ,Chou J,Janakos M,Strong VE,Coit DG,Brennan MF

更新日期：2011-03-01 00:00:00

abstract：PURPOSE:The purpose of this study was to obtain a comprehensive understanding of the impact of postoperative tumor marker (TM) normalization on survival after pancreatectomy for pancreatic carcinoma. We propose the concept of surgical RECIST based on residual tumor and TM status. METHODS:A total of consecutive patient...

journal_title：Annals of surgical oncology

authors： Motoi F,Rikiyama T,Katayose Y,Egawa S,Unno M

更新日期：2011-02-01 00:00:00

abstract：BACKGROUND:The rising incidence of incidental thyroid carcinoma (ITC) detected during fluoro-2-deoxy-D: -glucose (FDG)-positron emission tomography (PET)/computed tomography (CT) scanning poses a challenge to clinicians. The present study aims to critically evaluate the clinicopathological characteristics of ITC detect...

journal_title：Annals of surgical oncology

authors： Law TT,Lang BH

更新日期：2011-02-01 00:00:00

abstract：BACKGROUND:FOXC2 has been implicated in cancer progression through its induction of epithelial-to-mesenchymal transition. We analyzed the clinical significance of FOXC2 in esophageal cancer cases, in which early distant metastasis or invasion to nearby organs is an obstacle to treatment. METHODS:Quantitative reverse t...

journal_title：Annals of surgical oncology

authors： Nishida N,Mimori K,Yokobori T,Sudo T,Tanaka F,Shibata K,Ishii H,Doki Y,Mori M

更新日期：2011-02-01 00:00:00

abstract：BACKGROUND:The status of the sentinel lymph node is an important predictor for survival in melanoma patients, but it is still unclear if early removal of micrometastases by sentinel lymph node dissection (SLND) alters survival. A large series of melanoma patients from a single center with long-term follow-up was analyz...

journal_title：Annals of surgical oncology

authors： Satzger I,Meier A,Hoy L,Völker B,Kapp A,Hauschild A,Gutzmer R

更新日期：2011-02-01 00:00:00

abstract：BACKGROUND:There are few reports on a dual dye and isotope approach using laparoscopy in gastric cancer sentinel node mapping. The aim of this study is to evaluate the feasibility of laparoscopic sentinel basin dissection for gastric cancer using simultaneous indocyanine green (ICG) and (99m)Tc-antimony sulfur colloid ...

journal_title：Annals of surgical oncology

authors： Park DJ,Kim HH,Park YS,Lee HS,Lee WW,Lee HJ,Yang HK

更新日期：2011-01-01 00:00:00

abstract：BACKGROUND:We sought to identify genes associated with the progression and metastasis of esophageal squamous-cell cancer by comparing the expression profiles of normal, primary cancer, and metastatic cancer cells isolated with laser microdissection. METHODS:Oligo microarray analysis identified several lymph node-speci...

journal_title：Annals of surgical oncology

authors： Kita Y,Mimori K,Iwatsuki M,Yokobori T,Ieta K,Tanaka F,Ishii H,Okumura H,Natsugoe S,Mori M

更新日期：2011-01-01 00:00:00

abstract：BACKGROUND:To analyze the relationship of objective and subjective evaluation tools of breast aesthetics, we compare the results of the BCCT.core (breast cancer conservative treatment.cosmetic results) software, a semiautomated objective symmetry evaluation tool, with those of the Aesthetic Status of the BCTOS (Breast ...

journal_title：Annals of surgical oncology

authors： Heil J,Dahlkamp J,Golatta M,Rom J,Domschke C,Rauch G,Cardoso MJ,Sohn C

更新日期：2011-01-01 00:00:00

abstract：BACKGROUND:During the last few years, many surgeons have begun to utilize the LigaSure device or Harmonic scalpel to perform thyroid surgery. Several papers have demonstrated the benefits of these devices compared with traditional hand-tying techniques. The purpose of this study was to examine our institution's experie...

journal_title：Annals of surgical oncology

authors： Zarebczan B,Mohanty D,Chen H

更新日期：2011-01-01 00:00:00

abstract：INTRODUCTION:Radiation from medical imaging may induce cellular damage and increase the risk of cancer. While health care workers are restricted to an annual dose of 50 milliSieverts (mSv), the exposure to patients is not typically recorded. After breast-conservation therapy (BCT), patients are subjected to screening m...

journal_title：Annals of surgical oncology

authors： Marti JL,Dauer LT,Stempel M,Patil S,Kaplan JB,Montgomery LL

更新日期：2011-01-01 00:00:00

abstract：BACKGROUND:Postoperative recurrence of hepatocellular carcinoma (HCC) is a major problem after surgical resection. To date, adjuvant chemotherapy or other adjuvant modalities have not been proven effective in preventing or delaying recurrence. The aim of this prospective randomized study was to evaluate the effectivene...

journal_title：Annals of surgical oncology

authors： Xia Y,Qiu Y,Li J,Shi L,Wang K,Xi T,Shen F,Yan Z,Wu M

更新日期：2010-12-01 00:00:00

abstract：BACKGROUND:Positive peritoneal cytology is a predictor of poor survival in patients with gastric cancer. Our aim is to more clearly define the natural history of this cohort. METHODS:Review of a prospectively maintained gastric cancer database of patients who had diagnostic laparoscopy with peritoneal washings. Clinic...

journal_title：Annals of surgical oncology

authors： Mezhir JJ,Shah MA,Jacks LM,Brennan MF,Coit DG,Strong VE

更新日期：2010-12-01 00:00:00

abstract：BACKGROUND:Seed localization uses a radioactive source to identify nonpalpable breast lesions for excision; it is an emerging alternative to wire localization (WL). Previous single health system studies report decreased rates of re-excision and improved patient convenience with this technique. This study is the first t...

journal_title：Annals of surgical oncology

authors： Rao R,Moldrem A,Sarode V,White J,Amen M,Rao M,Andrews V,Euhus D,Radford L,Ulissey M

更新日期：2010-12-01 00:00:00

abstract：BACKGROUND:Epigenetic silencing of tumor-related genes by CpG island methylation is an important mechanism for the development of many tumors, including gastric carcinoma. Deregulation of transcription factor 4 (TCF4) by promoter methylation was recently shown to play a key role in gastric carcinogenesis. METHODS:The ...

journal_title：Annals of surgical oncology

authors： Joo JK,Kim SH,Kim HG,Kim DY,Ryu SY,Lee KH,Lee JH

更新日期：2010-12-01 00:00:00

abstract：BACKGROUND:Pseudoangiomatous stromal hyperplasia (PASH) is a benign localized fibrotic lesion in which clusters of spindle cells form cleftlike spaces, resembling ectatic vessels. Its relationship to breast cancer risk has not been characterized. MATERIALS AND METHODS:Histological presence of PASH was evaluated by rev...

journal_title：Annals of surgical oncology

authors： Degnim AC,Frost MH,Radisky DC,Anderson SS,Vierkant RA,Boughey JC,Pankratz VS,Ghosh K,Hartmann LC,Visscher DW

更新日期：2010-12-01 00:00:00

abstract：BACKGROUND:Thrombomodulin (TM) is a key molecule mediating circulation homeostasis through its binding to thrombin. The TM-thrombin complex can activate protein C and thrombin-activatable fibrinolysis inhibitor to form a tight clot. In many cancer tissues, decrease of TM expression may correlate with cancer metastasis....

journal_title：Annals of surgical oncology

authors： Huang MT,Wei PL,Liu JJ,Liu DZ,Huey-Chun H,An J,Wu CC,Wu CH,Ho YS,Yang YY,Chang YJ

更新日期：2010-12-01 00:00:00

abstract：BACKGROUND:We hypothesized that metastasis beyond the sentinel lymph nodes (SLN) to the nonsentinel nodes (NSN) is an important predictor of survival. MATERIALS AND METHODS:Analysis was performed of a prospective multi-institutional study that included patients with melanoma ≥ 1.0 mm in Breslow thickness. All patients...

journal_title：Annals of surgical oncology

authors： Brown RE,Ross MI,Edwards MJ,Noyes RD,Reintgen DS,Hagendoorn LJ,Stromberg AJ,Martin RC,McMasters KM,Scoggins CR

更新日期：2010-12-01 00:00:00

abstract：BACKGROUND:Pancreatic adenocarcinoma impinging the portal and/or superior mesenteric vein (PV-SMV) is classified as borderline resectable, and preoperative chemoradiation is recommended to increase the margin-negative resection rate. There is no consensus about what degree of venous impingement constitutes borderline r...

journal_title：Annals of surgical oncology

authors： Chun YS,Milestone BN,Watson JC,Cohen SJ,Burtness B,Engstrom PF,Haluszka O,Tokar JL,Hall MJ,Denlinger CS,Astsaturov I,Hoffman JP

更新日期：2010-11-01 00:00:00

abstract：BACKGROUND:The association between procedure volume and clinical outcomes has led many to advocate centralization of cancer procedures at high-volume centers (HVCs). Regional studies show practice patterns changing with increasing centralization of esophageal and pancreatic procedures at HVCs but little change for colo...

journal_title：Annals of surgical oncology

authors： Stitzenberg KB,Meropol NJ

更新日期：2010-11-01 00:00:00

abstract：BACKGROUND:The heterogeneous nuclear ribonucleoprotein (hnRNP) K is an essential RNA and DNA binding protein involved in gene expression and signal transduction. The role of hnRNP K in cancer is relatively understudied. However, several cellular functions strongly indicate that hnRNP K is involved in tumorigenesis. Onc...

journal_title：Annals of surgical oncology

authors： Wen F,Shen A,Shanas R,Bhattacharyya A,Lian F,Hostetter G,Shi J

更新日期：2010-10-01 00:00:00

abstract：BACKGROUND:Surgery is the standard treatment for primary, gastrointestinal stromal tumor (GIST); however, surgical resection often is not curative, particularly in large GIST. Five years after complete removal of their tumor, approximately half of treated patients relapse. Imatinib, an oral tyrosine kinase inhibitor (T...

journal_title：Annals of surgical oncology

authors： Hohenberger P,Eisenberg B

更新日期：2010-10-01 00:00:00

abstract：BACKGROUND:Guidelines recommend sentinel lymph node dissection (SLND) for patients with clinical stage I/IIA/IIB breast cancer; however, a significant fraction of patients do not undergo this procedure. We sought to identify factors associated with noncompliance with the SLND benchmark in early-stage breast cancer. MA...

journal_title：Annals of surgical oncology

authors： Olaya W,Wong J,Morgan JW,Truong C,Roy-Chowdhury S,Kazanjian K,Lum S

更新日期：2010-10-01 00:00:00

abstract：BACKGROUND:This prospective multicenter sentinel lymph node (SLN) trial investigated whether molecular analysis would improve the detection of SLN metastases and their prognostic value. We report mammaglobin quantitative real-time polymerase chain reaction (qRT-PCR) results and clinical outcome for 547 patients (mean f...

journal_title：Annals of surgical oncology

authors： Verbanac KM,Min CJ,Mannie AE,Lu J,O'Brien KF,Rosman M,Tafra L,ECU\/AAMC Sentinel Node Study Group.

更新日期：2010-10-01 00:00:00

abstract：BACKGROUND:Several studies have reported an increased rate of contralateral prophylactic mastectomy (CPM) in patients with unilateral breast cancer. This study reports on CPM trends from the American College of Surgeon's National Cancer Data Base (NCDB) diagnosed over a 10-year period. METHODS:Data about women diagnos...

journal_title：Annals of surgical oncology

authors： Yao K,Stewart AK,Winchester DJ,Winchester DP

更新日期：2010-10-01 00:00:00

abstract：BACKGROUND:Lymph node metastasis is widely accepted as one of the most important determinants of prognosis in colorectal cancer (CRC) patients. Therefore, there is an urgent need to identify molecular markers that can be used to predict lymph node metastasis. MATERIALS AND METHODS:Candidate genes were found using LMD ...

journal_title：Annals of surgical oncology

authors： Ozawa H,Iwatsuki M,Mimori K,Sato T,Johansson F,Toh H,Watanabe M,Mori M

更新日期：2010-09-01 00:00:00

abstract：BACKGROUND:Sentinel node biopsy (SNB) may represent an alternative to elective neck dissection for the staging of patients with early head and neck squamous cell carcinoma (HNSCC). To date, the technique has been successfully described in a number of small single-institution studies. This report describes the long-term...

journal_title：Annals of surgical oncology

authors： Alkureishi LW,Ross GL,Shoaib T,Soutar DS,Robertson AG,Thompson R,Hunter KD,Sorensen JA,Thomsen J,Krogdahl A,Alvarez J,Barbier L,Santamaria J,Poli T,Sesenna E,Kovács AF,Grünwald F,Barzan L,Sulfaro S,Alberti F

更新日期：2010-09-01 00:00:00

abstract：BACKGROUND:AJCC staging of pancreatic cancer (PAC) is used to determine prognosis, yet survival within each stage shows wide variation and remains unpredictable. We hypothesized that tumor grade might be responsible for some of this variation and that the addition of grade to current AJCC staging would provide improved...

journal_title：Annals of surgical oncology

authors： Wasif N,Ko CY,Farrell J,Wainberg Z,Hines OJ,Reber H,Tomlinson JS

更新日期：2010-09-01 00:00:00

abstract：BACKGROUND:Biomarkers for accurate diagnosis of early hepatocellular carcinoma (HCC) are limited in number and clinical validation. We applied SELDI-TOF-MS ProteinChip technology to identify serum profile for distinguishing HCC and liver cirrhosis (LC) and to compare the accuracy of SELDI-TOF-MS profile and alpha-fetop...

journal_title：Annals of surgical oncology

authors： Chen L,Ho DW,Lee NP,Sun S,Lam B,Wong KF,Yi X,Lau GK,Ng EW,Poon TC,Lai PB,Cai Z,Peng J,Leng X,Poon RT,Luk JM

更新日期：2010-09-01 00:00:00

abstract：BACKGROUND:Percutaneous biliary drainage (PBD) is used to relieve malignant bile duct obstruction (MBO) when endoscopic drainage is not feasible. Little is known about the effects of PBD on the quality of life (QoL) in patients with MBO. The aim of this study was to evaluate changes in QoL and pruritus after PBD and to...

journal_title：Annals of surgical oncology

authors： Robson PC,Heffernan N,Gonen M,Thornton R,Brody LA,Holmes R,Brown KT,Covey AM,Fleischer D,Getrajdman GI,Jarnagin W,Sofocleous C,Blumgart L,D'Angelica M

更新日期：2010-09-01 00:00:00

abstract：BACKGROUND:Ultrasound (US)-guided fine-needle aspiration biopsy (FNAB) is an accurate, reliable, and simple procedure to perform, and it is nowadays accepted as a standard diagnostic method for the differential diagnosis of thyroid nodules. However, a major limitation of US-FNAB is indeterminate cytology results at a t...

journal_title：Annals of surgical oncology

authors： Yoon JH,Kwak JY,Kim EK,Moon HJ,Kim MJ,Kim JY,Koo HR,Kim MH

更新日期：2010-08-01 00:00:00

abstract：BACKGROUND:Poly(ADP-ribose) polymerase (PARP) is an important regulator of programmed cell death in response to alkylating agents such as temozolomide (TMZ). The goal of this study was to determine if a systemically administered PARP-inhibitor (INO-1001) could augment the efficacy of TMZ in a rat model of extremity mal...

journal_title：Annals of surgical oncology

authors： Toshimitsu H,Yoshimoto Y,Augustine CK,Padussis JC,Yoo JS,Angelica Selim M,Pruitt SK,Friedman HS,Ali-Osman F,Tyler DS

更新日期：2010-08-01 00:00:00